SDS and Chemical Management Software with Embedded Agentic AI and Backed by Industy's only Error-Free Guarantee on SDS Data

3E Protect is a chemical safety and compliance management platform that gives your entire organization, from frontline workers to corporate EHS leaders, immediate access to the safety data, regulatory intelligence, and expert support they need to work safely and stay compliant.

At its core, 3E Protect is your single source of truth for Safety Data Sheets (SDS), chemical inventory, hazard classifications, and regulatory obligations across every facility and geography. But it goes far beyond document storage. 3E Protect combines a library of more than 10 million SDS with full-service obtainment and data indexation, AI-powered chemical intelligence, built-in regulatory screening against GHS, OSHA HazCom, REACH, CLP, WHMIS, and 200+ frameworks, plus  24/7/365 live access to EHS specialists for spill response, poison control, and emergency guidance — in a single subscription.

Whether you’re managing chemicals at a single site or across a global enterprise, 3E Protect replaces fragmented binders, spreadsheets, and disconnected tools with a unified platform that keeps your people safe, your operations compliant, and your teams focused on higher-value work.

3E Protect serves organizations of all sizes, from single-facility operations to global enterprises, across process and discrete manufacturing, pharmaceuticals, retail, food and beverage, healthcare, energy, and any industry where chemicals are used, stored, shipped, or disposed of.

Within those organizations, 3E Protect supports the full range of roles involved in chemical and workplace safety:

• EHS and Safety Managers who need fast, reliable access to hazard data for the chemicals their teams handle every day, and the tools to manage inventory, approvals, and compliance across sites.
• Environmental and Sustainability Leaders responsible for regulatory reporting (such as SARA Title III and RCRA), chemical inventory screening, and tracking evolving regulations that affect operations.
• Occupational Health and Industrial Hygiene Professionals who assess chemical exposure risks, evaluate PPE requirements, and ensure worker safety programs are grounded in accurate, current data.
• Operations, Warehouse, and Facilities Managers on the front lines who need instant SDS access, secondary container labels, and clear guidance when incidents happen.
• C-Suite and Corporate Leadership driving safety-first culture, managing enterprise risk, and ensuring consistency across newly acquired or geographically dispersed business units.

If your people work with chemicals, 3E Protect is built for them.

An SDS database gives you documents. 3E Protect gives you chemical intelligence.

The difference matters. A database stores PDFs. 3E Protect captures structured data fields from every SDS, including GHS and CLP classifications, composition percentages, PPE requirements, handling and storage guidance, first aid measures, transportation classifications, and REACH registration data—and makes that data searchable, reportable, and ready for integration with your other enterprise systems.

That structured data unlocks capabilities a document repository simply cannot provide: screening your entire chemical inventory against 80+ global regulatory lists, managing chemical approval workflows before a new product ever enters your facility, generating secondary container labels that comply with GHS requirements, classifying chemicals for fire code, transportation, and waste disposal, and alerting you automatically when an SDS revision changes the hazard profile of a product you use.

Beyond the data, 3E Protect includes services no SDS database offers: 24/7/365 live access to spill response specialists, poison control physicians, and dangerous goods transportation experts via our EHS Call Center. When a chemical incident happens, you don’t search a database, you call a specialist.

The bottom line: an SDS database tells you where to find a document. 3E Protect tells you what’s in your inventory, what it means for your compliance obligations, and what to do when something goes wrong.

Data quality is foundational to everything 3E Protect delivers, and we treat it as an accountable outcome, not an aspiration.

Our dedicated Data Acquisition Center captures structured data from SDS across dozens of languages using strict quality control procedures, and every record is traceable back to its source document. We are investing heavily in AI-powered indexation and validation to extract and verify critical hazard, PPE, and regulatory fields, increasing both speed and accuracy while maintaining expert human oversight at every step.

This commitment is formalized through the 3E Error-Free Guarantee: if an indexation error is identified, 3E corrects it and applies root-cause analysis to prevent recurrence. It’s an accountability loop, not just a promise. You get confidence that the data driving your compliance decisions, audit reports, and safety protocols is accurate, backed by a guarantee with real consequence.

Our Supplier Relations Specialists continuously monitor manufacturer updates and proactively obtain the latest SDS revisions so your inventory stays current. Combined with automated revision alerts and transparent obtainment tracking, you always know the status of every document in your catalog.

The result: your EHS team spends less time validating data and more time on strategic compliance and safety initiatives.

Yes, scaling across facilities and geographies is what 3E Protect is built for.

The platform supports unlimited users, unlimited locations, and unlimited documents including SDS in all supported languages. There are no per-seat fees or per-facility caps that force you to ration access. Everyone who needs safety data can access it, from a plant floor in Texas to a warehouse in Stuttgart.

The interface is localized in 31 languages, including English, Spanish, French, German, Japanese, Korean, Chinese (simplified and traditional), Portuguese, and many more. SDS are available in the jurisdiction and language required for each location, so your teams always see data that’s relevant to their local regulatory environment.

For organizations managing complex, multi-site operations, 3E Protect provides site-specific chemical inventories, location-level regulatory reporting, and centralized visibility across your entire enterprise. Whether you’re integrating a newly acquired facility, rolling out a consistent chemical approval process globally, or consolidating disparate SDS management systems into one platform, 3E Protect is designed to grow with you.

Our implementation team offers multiple onboarding options, from submitting a product list for us to match and build your catalog, to deploying inventory specialists for on-site assessments at your North American locations, so you can get up and running at the scale and pace your business requires.

3E Protect uses a value-based pricing model designed to be simple, predictable, and aligned with the value you receive.

There are no per-user fees, no document caps, and no overage charges, your subscription covers unlimited users, unlimited documents, and unlimited EHS hotline access.

Additional add-on capabilities, such as transportation and waste classification, container tracking, regulatory reporting, and integration solutions, are available based on your specific needs.

When a chemical emergency happens, every second counts. 3E Protect includes built-in, 24/7/365 access to our EHS Call Center staffed by trained specialists who provide real-time, expert guidance the moment you call.

For chemical spills: Our spill specialists provide immediate guidance on hazard assessment, containment, personal protective equipment, absorbent selection, storage container requirements, and, critically, whether the incident triggers agency reporting requirements based on federal, state, and local thresholds. For incidents requiring on-site response, 3E can dispatch emergency response professionals and equipment while acting as your virtual incident commander.

For chemical exposures: Board-certified physicians, toxicologists, and poison control specialists are available around the clock to provide medical advice for skin and eye contact, inhalation, and ingestion incidents. Veterinary toxicologists are also on staff for animal-related exposures.

For transportation incidents: Dangerous goods specialists can provide real-time emergency response guidance for hazardous materials incidents during shipment, helping you meet DOT 49 CFR requirements for an emergency response telephone number.

Translation support is available in over 300 languages, ensuring your global workforce can communicate effectively during a crisis. Every call is documented with detailed incident records for your compliance files.

Because 3E Protect’s SDS management and emergency response services are fully integrated on one platform, the specialists responding to your call already have access to your chemical inventory and SDS data, eliminating the delays that come from managing separate vendors.

Yes. 3E Protect is designed to work directly with your existing technology ecosystem, not replace it.

Through our REST API and integration solutions, 3E Protect delivers SDS documents and structured chemical data directly into the enterprise systems your teams already use. This means safety, compliance, procurement, and operations teams can access the chemical intelligence they need without leaving their primary workflow.

3E Protect integrates with a wide range of platforms, including:

• ERP systems such as SAP EHS and SAP S/4HANA for product compliance, where 3E has a strategic development partnership to co-deliver embedded regulatory content and vendor SDS management
• EHS and EHSQ platforms including Cority, Enablon, Intelex, and ServiceNow
• Supply chain and procurement tools such as SAP Ariba
• Inventory and chemical management systems including Jaggaer RMM, Kelaroo KRMS, and Biovia CISPro
• 3E’s own portfolio including 3E Exchange for supply chain compliance, 3E Generate and 3E ERD for SDS authoring, and 3E Insight for regulatory intelligence

Integration options include API-based data delivery for SDS documents, indexed chemical data fields, and regulatory content. Single sign-on (SSO) via SAML is supported for Enterprise customers, enabling seamless authentication through your existing corporate credentials. SDS Hosting provides a branded, public-facing SDS access portal launched from your own website.

Our team works with you during implementation to configure the right integration approach for your environment.

Regulatory compliance isn’t a feature of 3E Protect, it’s the foundation the entire platform is built on.

3E Protect helps you meet compliance obligations across multiple regulatory frameworks by combining accurate chemical data, built-in regulatory intelligence, expert services, and auditable recordkeeping:

Hazard Communication (HazCom/GHS): Ensure every worker has access to current SDS in the appropriate language and jurisdiction. Generate secondary container labels compliant with GHS and EU CLP requirements. Maintain a complete, auditable SDS archive with full revision history.

Chemical Inventory Screening: Screen your inventory against 3,000+ regulatory and custom lists to identify substances of concern, restricted chemicals, and emerging obligations like PFAS regulations. The Chemical Analysis module lets you build custom screening lists aligned with your internal policies and “black lists.”

U.S. Regulatory Reporting (EPCRA/SARA Title III & RCRA): Enterprise customers gain access to facility-level regulatory reporting capabilities and compliance calendars that help you track reporting thresholds, deadlines, and obligations for hazardous chemical inventory and release reporting.

EU REACH Compliance: Track REACH registration numbers, identify products with extended Safety Data Sheets (eSDS) and exposure scenarios, and support Unique Formula Identifier (UFI) requirements.

Chemical Approval Workflows: Control which chemicals enter your facilities through configurable approval workflows that route requests through the appropriate reviewers, EHS, procurement, industrial hygiene—before a product is ever used on site.

Classification and Regulatory Alerts: Receive automatic notifications when SDS revisions, classification changes, or regulatory updates affect the products in your inventory—so you can act before a compliance gap becomes a violation.

Emergency Compliance: Our 24/7/365 spill hotline helps you determine reporting obligations in real time, identifying whether a spill meets or exceeds applicable federal, state, or local reporting thresholds and connecting you with the right authorities.

For more than 35 years, over 5,000 customers worldwide, including nine of the top ten chemical manufacturers, have trusted 3E to help them stay compliant. That regulatory expertise isn’t just embedded in our technology. It’s what we do.

SDS management software is a platform that centralizes the storage, retrieval, distribution, and maintenance of Safety Data Sheets (SDS) for an organization’s chemical inventory. It replaces paper binders and spreadsheets with searchable digital access to SDS data, hazard classifications, PPE requirements, storage guidance, and regulatory information. Enterprise SDS management platforms like 3E Protect go further by adding chemical inventory management, regulatory screening, AI-powered chemical intelligence, and live expert support.

3E Protect supports compliance with 200+ global regulatory frameworks, including GHS, OSHA HazCom, EU REACH (SVHC screening), CLP Regulation, WHMIS (Canada), California Proposition 65, and chemical safety regulations across 100+ countries. The platform’s regulatory intelligence is continuously updated by 3E’s team of regulatory scientists to reflect current requirements, so organizations always screen chemicals against the latest standards.